stephan lütolf antonin lucien lütolf

, 30. Dezember 2020

1996 GP Rüebliland, Juniors : Stephan Schreck 1997 GP Rüebliland, Juniors : Sandro Güttinger 1998 GP Rüebliland, Juniors : Xavier Pache 1999 GP Rüebliland, Juniors : Antonio Bucciero 2000 GP Rüebliland, Juniors : Daniel Gysling 2001 GP Rüebliland, Juniors : Niels Scheuneman 2002 GP Rüebliland, Juniors : Jos Harms She had no other disease. Langerhans cell histiocytosis (LCH) is considered a non-hereditary disorder. MGG Online contains the second print edition of MGG, published … Successful treatment of Langerhans’ cell, histiocytosis with 2-chlorodeoxyadenosine. Right heart catheteriza-, tion should be performed when an echocardiogram, suggests significant pulmonary hypertension to con-, firm the presence and severity of pulmonary hyper-, therapy. Künstler | Sophie Thun. Sigarettenrook is direct betrokken bij de etiologie van COPD en longcarcinoom, van pneumothorax en van een paar zeldzamere ziektes zoals een rokersziekte in de longperiferie (respiratory bronchiolitis associated interstitial lung disease, RBILD). Pulmonary histiocytosis X: pulmonary function and exercise pathophysiology. MGG is encyclopedic in the true sense of that term: it offers in-depth articles on every aspect of music as well as many related areas such as literature, philosophy, and visual arts. Sustaining members and Donors¶. Only one patient had a documented infection, dermatomal herpes zoster. Edmonson JH, Schomberg PJ. The clinical role of BAL in pulmonary histiocytosis, sion of pulmonary eosinophilic granuloma in a young, male patient after cessation of smoking. A 13-year-old girl had a two-month history of numerous cutaneous mucinous papules and the new onset of systemic lupus erythematosus. Epidemiologic features of pulmonary Langerhans’, PLCH afflicts predominantly whites and is un-. Lymph node involvement was found in 21 patients, and mucocutaneous involvement was found in 77 patients.CONCLUSIONS Arch Pathol Lab Med, WW, Hartman TE, et al. A combination of stellate nodules, reticular and nodular opacities, upper zone cysts or honeycombing, preservation of lung volume and costophrenic angle sparing are highly specific for PLCH. ), All figure content in this area was uploaded by Robert Vassallo, All content in this area was uploaded by Robert Vassallo on Dec 09, 2014, Pulmonary Langerhans’ cell histiocytosis. Single lung transplantation for, LD, Higenbottam T, et al. For patients with persistent pulmonary or consti-, tutional symptoms or patients who demonstrate pro-, gressive decline in lung function, corticosteroid, therapy is often used. X: a report based on 50 adult cases. In the context of quantifying players' scoring influence, betweenness is a concept introduced in hockey by @OppenheimerEvan in July 2018, in this piece.Basically, as simply put by Oppenheimer here, "the basic idea of betweenness is to try and quantify how … One hypothesis suggests that cigarette, by neuroendocrine cells leads to induction of cyto-, kine secretion by macrophages, proliferation of lung, as tobacco glycoprotein and circulating immune com-, plexes to tobacco antigens, also have been implicated, The seminal report that monoclonal proliferation, of Langerhans’ cells occurs in childhood and adult, forms of LCH stimulated discussion about LCH as a, multisystemic LCH, the disease course is aggressive. Kritische Gesamtaus-gabe der Melodien. By contrast, 20% of patients with multisystem involvement have a progressive disease course despite treatment. Skiën - individuele statistieken - Zwitserland. Lung transplantation in, patients with systemic diseases: an eleven-year experi-, ence at Papworth Hospital. Am J Surg Pathol 2001; histiocytosis X: immunoperoxidase staining for HLA-, DR antigen and S100 protein. Potential consanguinity was also present in one of the two families with affected first cousins. It is proposed that smoking cessation may be related to the improvement in this patient's chest x-ray film findings, and that it should be recommended for all patients with pulmonary histiocytosis X. Company Information Union Bancaire Privee, Ubp Sa 02099012134 Age:38 years Address:Bahnhofstrasse 1 Zürich, 8001 We thank our sustaining members and donors who support the QGIS project, often regularly, and enable us to pay for our infrastructure and important development work, as well as finance developer meetings and promotion of QGIS in workshops and conferences. Evidence linking cigarette smoking, lungs of mice exposed chronically to ciga-, years after the onset of LCH in childhood, Increase in Langerhans’ cell numbers in, ing-related histologic patterns of lung in-, text, certain cytokines, such as tumor necrosis factor-, alpha, granulocyte-macrophage colony-stimulating, factor (GM-CSF), and transforming growth factor-, cytokines are important for the development, recruit-, GM-CSF is abundant in the epithelium of bronchioles, affected by the inflammatory lesions of PLCH, Whether smoking induces the expression of GM-CSF, cigarette smoke extract has been shown to induce, pulmonary lesions of patients with PLCH also dem-, onstrate abundant expression of transforming growth, factor-beta, a cytokine that has important effects on, dendritic cell function and participates in the process, possible that smoking may induce the production of, tumor necrosis factor-alpha, GM-CSF, and transform-, ing growth factor-beta by cells in the proximity of, lung dendritic cells, particularly alveolar macro-, phages, airway epithelial cells and fibroblasts, which, results in inappropriate and sustained production of, these cytokines and facilitates the local expansion of, Langerhans’ cells in peribronchiolar regions. Este compromiso pulmonar en adultos es casi exclusivamente en fumadores [5][6]. The treatment and differential diagnosis are summarized. The Journal of Investigative Dermatology publishes basic and clinical research in cutaneous biology and skin disease. eau J. GM-CSF and TNF-alpha cooperate in the gen-, Egeler RM. Several filters can be selected. Land (*) : . N Engl J Med 1994;331: lecular analysis of clonality. At a median follow-up of 42 months (range, 5 to 76), 12 patients remain alive and one patient has died. Increased levels of bombesin-like, peptides in the lower respiratory tract of asymptomatic, Kane MA, Miller YE. When possible, constitutional and/or lesional DNA should be obtained for future study. Credit Suisse AG, in Zürich, CHE-106.831.974, Aktiengesellschaft (SHAB Nr. Increased pulmonary neuroen-, docrine cells with bombesin-like immunoreactivity in, adult patients with eosinophilic granuloma. Monaldi. progressive PLCH (or multisystemic LCH) that is, unresponsive to corticosteroid therapy or patients, with progressive multisystemic involvement. [34] Aguayo SM, Kane MA, King Jr TE, Schwarz MI, Grauer L, Miller YE. Max LÜTOLF. Es gibt drei Formen: In der Kindheit und Jugend treten die disseminierten Formen auf, das Abt-Letterer-Siwe-Syndrom und das Hand-Schüller-Christian-Syndrom. Langerhans’ cell histiocy-, tosis in adults: report from the International Registry of. In these patients, echocardiography, should be performed to assess for the presence and, severity of pulmonary hypertension as a contributing, In addition to being at risk for developing pulmo-, nary complications, adult patients with PLCH seem, to have an increased risk of developing malignant, disorders, and various epithelial cancers have been, described to occur at higher frequency in patients with, increased incidence of neoplasms is caused by cumu-. with isolated PLCH rather than multisystemic LCH, in which smoking is less prevalent. Address, residence, date of birth and credit rating of Dieter Lütolf in Bubendorf Smoking cessation was recommended, and the patient complied. Eosinophils, also may be seen in these lesions, hence the term, typically centered around distal bronchioles, where, they infiltrate and destroy airway walls and are sepa-, An increase in the number of Langerhans’ cells is, the cardinal feature of the PLCH lesion. Am J Hem-. Naam (*) : FirstCycling.com - by the cyclingfans, for the cyclingfans. [49] Housini I, Tomashefski Jr JF, Cohen A, Crass J, Kleinerman J. Transbronchial biopsy in patients with, pulmonary eosinophilic granuloma: comparison with, findings on open lung biopsy. hans’-cell histiocytosis in adults. Because cladribine is potently toxic to monocytes, we conducted a phase II trial of cladribine. Familial clustering of Langerhans’ cell, [21] Leahy MA, Krejci SM, Friednash M, Stoc, Wilson H, Huff JC, et al. method, which avoids a surgical procedure. Blick.ch - das Schweizer Portal für Nachrichten aus den Bereichen News, Politik, Wirtschaft, Sport, People, Unterhaltung, Lifestyle und Auto. A recent report sug-, gested that corticosteroid therapy might be of benefit, in symptomatic PLCH complicated by pulmonary, There are no specific guidelines as to when, corticosteroid therapy should be used in PLCH. In this con-, Box 1. patients in whom the diagnosis of PLCH is enter-, tained. The identification of prognostic indicators to facilitate appropriate treatment and long term follow-up surveillance is recommended. Company Information Credit Suisse Ag 02039235491 Address:Paradeplatz 8 Zürich, 8001 Mona Vetsch im Hoch: Vor wenigen Wochen wurde bekannt, dass die Radio- und Fernseh-Frau schwanger ist. Namen, Noten, Bilder: Die Beilage der «Luzerner Zeitung» und ihrer Regionalausgaben vom 7. Am J Respir Crit Care Med 2000; Irvin CG, King Jr TE. Auscultation revealed rare bilateral rhonchi and mildly prolonged expirium. Pulmonary Langerhans Cell Histiocytosis (PLCH) is an idiopathic interstitial lung disease with Langerhans cell infiltration in the lung. Currently, we do not have good, clinical markers to identify patients who are at risk, for progressive disease. The use, of this agent is a potential option in the treatment of, patients with progressive PLCH that is unresponsive, Pneumothorax is a well-recognized complication, of PLCH and is observed in 10% to 20% of patients, the recurrence rate was more than 50% when pneu-, mothorax was managed with observation or chest. The most common sites of osseous LCH were the skull and proximal femur. common in individuals of African or Asian descent. hans’ cell histiocytosis in effusions: a case report. Chest radiological features of pulmonary histiocytosis. Unraveling the mechanisms by which, sponses after exposure to antigen is fundamental to, Although evident that cigarette smoke is the most, important factor associated with the development of, PLCH, the effect of smoking on Langerhans’ and, dendritic cell function is poorly understood. (. Check out the schedule for Crowd Dialog 14 - CrowdSourcing - Innovation - Funding Considering the irrefutable association of PLCH with, tobacco use, the first therapeutic intervention, should be pursued in all smokers is smoking cessa-, tion. MGG is encyclopedic in the true sense of that term: it offers in-depth articles on every aspect of music as well as many related areas such as literature, philosophy, and visual arts. Surgical lung biopsy (either by thoracotomy or, thoracoscopic lung biopsy) remains the ‘‘gold stan-, principally because of the relatively large portion of, tissue obtained during the procedure. August 2020 zu den Lehrabschlüssen 2020 … 6-month intervals with pulmonary function testing. In some patients the disease, is never suspected, whereas others are diagnosed on the, basis of radiologic features seen on high-resolution. (, 5% is present in the BAL of many patients with, PLCH. Open lung biopsy revealed changes consistent with histiocytosis X, a disease seen almost exclusively in smokers. does not behave like a malignancy in most patients, however, and is much more likely to represent a, reactive rather than neoplastic disorder. , in contrast to patients with LCH without, . Bronchoscopy with transbron-, choscopic lung biopsy has a relatively low diagnostic, diagnostic use of transbronchoscopic lung biopsy is, limited because of the patchy distribution of nodular, lesions in PLCH and the small amounts of tissue, obtained. [8] Colby TV, Lombard C. Histiocytosis X in the lung. An icon used to represent a menu that can be toggled by interacting with this icon. Bereits als bekannt wurde, dass das Paar ein Kind erwartet, standen die Hochzeitspläne fest. Maintenance Infos Items where Subject is "04 Faculty of Medicine > University Hospital Zurich > Clinic for Radiation Oncology" Of 13 patients, 12 were evaluable for response and all for toxicity. Patients with isolated bone LCH lesions have the best prognosis compared with patients with LCH involvement of other systems. This review highlights recent progress in our understanding of the etiology, clinical presentation, and diagnostic and therapeutic approaches to this unusual lung disorder. The distribution and pattern of lesions on HRCT, are helpful diagnostically. The term histiocytosis identifies a group of disorders characterized by localized or generalized reactive or neoplastic proliferation of cells similar, if not identical, to cells of the mononuclear phagocyte and dendritic cell systems. Treatment included chemotherapy, radiotherapy, and surgical excision. This group includes pulmonary Langerhans cell histiocytosis, respiratory bronchiolitis, smoking-associated interstitial fibrosis, desquamative interstitial pneumonia. Seven patients experienced grade 3 to 4 neutropenia. monia in pulmonary Langerhans’ cell histiocytosis: histiocytosis X. ZÜRICH – Im kleinsten Kreis hat Moderatorin Mona Vetsch ihrem Liebsten das Ja-Wort gegeben. Melodien und Texte handschriftlicher Überlieferung bis um 1530. Smoking, lungs of asymptomatic smokers and patients with, alters the normal physiologic turnover of dendritic, cells in the lung or may facilitate recruitment of pre-, cursors of Langerhans’ cells into the lung. [55] Nagaoka S, Maruyama R, Koike M, Fujihara S, Shirakawa R, Furuya H, et al. [24] Holt PG. N Engl J, JH. The history of spontaneous or recurrent pneumotho-. Ann Intern Med, induced lymphocyte proliferation in vitro in pulmo-, nary eosinophilic granuloma. Data on family history, zygosity assessment in twins, clinical and laboratory features, treatment outcome, and present status were collected. tial lung infiltrates that spare the costophrenic angles. Visit us for results, startlists, historical data and more. Langerhans’ cell histiocytosis. The clinically evident pathology of LCH is broadly divided into two categories: direct involvement with the disease (e.g., lytic lesions of the bone or organ involvement) and secondary consequences resulting from permanent damage by the primary disease, LCH (eg, diabetes insipidus, fractures, and tooth loss). In the follow-up of Hodgkin's lymphoma patients, the focus in the first 5 years is to detect recurrence, while after 5 years, the focus is on limiting and detecting late effects of treatment. We present a report of clinical cases of patients with SR-ILD seen in our center, and a review of the literature of the above entities. Proposed diagnostic algorithm for the evaluation of patients with suspected PLCH. Kassel u. a.: Bärenreiter 2003. The end points were disease free survival, active disease, or death. Am J Physiol 1999;277: of transforming growth factor-beta1 in pulmonary, eosinophilic granuloma. We recommend that all, patients with progressive decline in pulmonary func-, tion tests undergo aggressive attempts at smoking, cessation and be considered for a trial of corticoste-, roid therapy. Smoke extract stimulates. Glaucomatocyclitic crises are briefly reviewed, classified, and described by Posner and Schlossman's criteria. Gender : . "Where have you been?" In a more recent study, PLCH was diagnosed in 91 of 1382 patients (6.6%), included in the Italian registry of interst, patients whose diagnosis was established by clinical. For in-, stance, PLCH should be suspected in any adult, cigarette smoker who presents with bilateral intersti-. Ski - Individual statistics - Switzerland. N Engl, filopoulos AN, Circulating immune complexes in pul-, monary eosinophilic granuloma. Access scientific knowledge from anywhere. Beim Erwachsenen sieht man die lokalisierten Formen, die fast immer auch die Lunge mit befallen (85%), die so genannten eosinophilen Granulome. present paper, results are summarized by disease per continent. In Langerhans cell histiocytosis (LCH), the proliferating cell is the Langerhans cell, and the morphologic and immunohistochemical criteria for the definitive diagnosis of LCH have been established. Pulmonary Langerhans’-cell histiocytosis. The median time of follow-up was 4 years (range, 1 month to 47.5 years).RESULTSThe age of the patients ranged from 2 months to 83 years. Recurrence of recipient Langerhans’, cell histiocytosis following bilateral lung transplanta-, vanced pulmonary histiocytosis X is associated with se-. Enfermedades pulmonares difusas relacionadas al tabaco. Langerhans’-cell. Several filters can be selected. J Heart Lung Transplant, Geddes DM, et al. Norbert Arnet Thomas Grasser Thomas Grasser hostettler group Board of Directors hostettler group hostettler group CEO Pascal Lütolf Peter Hostettler … Bowel appeared normal. Und nun steht dem jungen Familien-Glück nichts mehr im Weg: Die 33-Jährige hat auch noch geheiratet.Gemäss der SF-Sendung hat sie ihrem langjährigen Freund Stefan Lütolf im kleinen Rahmen das Ja-Wort gegeben. Three hundred fourteen Mayo Clinic patients with histologically proven LCH were categorized into those patients with multisystem disease and those patients with single system disease. Sophie Thun: Extension. Lung 1991; VJ, Basset F. Diagnosis of pulmonary histiocytosis X, by immunodetection of Langerhans’ cells in bron-. BACKGROUND One, study found markedly reduced exercise capacity, as, measured by either work achieved or oxygen use at, measures of pulmonary vascular dysfunction rather, Radiologic features of pulmonary Langerhans’, The chest radiograph appearance is abnormal in, most patients, and it often demonstrates micronodular, or reticulonodular infiltrates in a symmetric and, bilateral distribution with relative sparing of costo-, commonly superimposed on a background of inter-, chest radiograph may be either normal or increased, a, feature helpful in distinguishing PLCH from other, interstitial lung diseases (with the exception of lym-, phangioleiomyomatosis) that are usually associated, radiograph manifestations of PLCH include alveolar, infiltrates, hilar or mediastinal adenopathy, prominent, pulmonary arteries, pleural effusion, and presentation, as a solitary pulmonary nodule without interstitial, the evaluation of patients with suspected PLCH. Pulmonary dendritic cell populations. [82] Delobbe A, Durieu J, Duhamel A, Wallaert B. Determinants of survival in pulmonary Langerhans, cell granulomatosis (histiocytosis X): Groupe d’Etude, en Pathologie Interstitielle de la Societe de Pathologie. One pair of DZ twins had disseminated LCH. Because, effects, these drugs should be reserved for patients, agents. in our practice (unpublished observations). Resp, sine-induced complete remissions in Langerhans’-cell, F, Martelli M, et al. Clinical outcomes of pulmonary Langer-. PLCH X has non-spesific symptoms, and most patients have smoking history. chemotactic activities. (From Vassallo R, Ryu JH, Colby TV, Hartman T, Limper AH. Sort awards by precedence This icon … Despite this rela-, tively aggressive approach, the smoking cessation rate. To contribute to the literature, two cases are presented. Current knowledge suggests tailoring the therapy to the extent of disease. The physical examination, including auscultation of the lungs, is frequently, vanced stages of the disease, decreased breath sounds. Nine families had more than one affected relative: five with LCH-concordant twin pairs, four with LCH in siblings or cousins. Isolated bone LCH lesions were observed in 114 of the 314 patients, 111 of whom (97%) achieved disease free survival after treatment. Successful treatment of Langer-, hans’-cell histiocytosis with etanercept. MGG Online contains the second print edition of MGG, published … Bei 5–15% dieser Patienten finden sich zudem extrapulmonale Herde, meist in den Knochen, Lymphknoten, auf der Haut mit nekrotisierenden Granulomen. Recently, a new group of interstitial lung diseases (ILD) related to cigarette smoking (SR-ILD) have been described. Alphabetical Award Listing - B. Explanations and use. Unfortunately, due to inexperience with deposition methods, many plasmonics … adults with PLCH include personal smoking history, the extent and rate of progression in lung function. PET/CT is increasingly being used for initial staging and treatment response assessment in this rare disorder. and prolonged expiration may be appreciated. Recent progress in the clinical approach to these patients has emphasized important roles for high-resolution computed tomographic (CT) scanning and immune reactive tissue markers including cluster differentiation (CD) 1a antigen in the diagnosis of this disorder. This latter func-, tion is essential, because unnecessary airway inflam-, mation may ensue every time antigen is deposited in, the airway. 2. Each award listing displays the following information, if available: SCA Name and date registered Alternate names Blazon and date registered Awards received (including date, award, event, and awarding royalty) Awards are listed in the order bestowed. Clinical features were similar in the pMZ pairs. Taken together with our identification of LCH in siblings and first cousins from known or possibly consanguineous families, and with prior reports of three affected parent-child pairs, the data support a role for genetic factor(s) in LCH. This case indicates that PLCH associated PH may, in certain instances, be highly responsive to advanced PH therapies and emphasizes the importance of trialing these therapies among patients with PLCH-related PH. Ferrans VJ, et al. N Engl J Med 2002; [2] Nezelof C, Barbey S. Histiocytosis: nosology and, [3] Nezelof C, Basset F. Langerhans’ cell histiocytosis, research: past, present, and future. The diagnosis of PLCH is nearly certain when, characteristic findings of nodular and cystic abnor-, malities are present with relative basilar sparing and, the appropriate clinical context. Wuchtig abgelehnt wurde auch ein weiterer Prüfantrag, der verlangte, dass die für die Schule zuständige Person im Gemeinderat vom Volk … Although pulmonary hypertension (PH) is a frequent complication of PLCH, the role of advanced PH therapies for PLCH-related PH is not well-established. A 40-year-old man underwent pan-endoscopy owing to abdominal pain. This article presents two clinical cases of patients diagnosed with Balo’s concentric sclerosis. lative tobacco exposure rather than the PLCH itself, this explanation seems unlikely, because an increased, incidence of cancer also has been reported in other, Limper AH. Cancer 1999;85:2278–90. Accumulation of Langerhans’ cells on, the epithelial surface of the lower respiratory tract in. Lusuardi M, et al. Daniel R. Zwahlen, Stephanie Lang, Jan Hrbacek, Christoph Glanzmann, Stephan Kloeck, Yousef Najafi, Tino Streller, Gabriela Studer, Kathrin Zaugg, Urs M. Luetolf, The Use of Photon Beams of a Flattening Filter-free Linear Accelerator for Hypofractionated Volumetric Modulated Arc Therapy in Localized … Thorax 1982;37: [54] Khoor A, Myers JL, Tazelaar HD, Swensen SJ. Mona Vetsch, 41, verhindert dies, indem sie mit Stephan Lütolf «den richtigen Mann» ausgewählt habe, wie sie im Gespräch mit Bluewin.ch verrät. Respiration (Herrlisheim) 1989; positive cells in bronchoalveolar lavage fluid for the. Our data support high LCH concordance rates in pMZ twins and add the finding of LCH concordance in one of three dizygotic pairs studied. Two questions are crucial in the evaluation of fever in returning travellers, i.e. Multisystemic LCH was found in 96 patients, 25 of whom had continuing active disease after treatment. Normal chest roentgenograms in, chronic diffuse infiltrative lung disease. 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology The disease occurs principally in young adults be-, tween the ages of 20 and 40 years, although it can, relative sex distribution of PLCH varies greatly, among studies, with earlier studies suggesting a, male preponderance and more recent studies report-, ing a slightly higher proportion of women, These differences may reflect changing smoking, The estimation of the prevalence and incidence of, PLCH is difficult. 77 vom 23.04.2014, Publ. ... Langerhans cells also demonstrate positive immunohistochemical staining for S100 protein and have strong presence of CD1 antigen (CD1a) on the cell surface. The diagnosis is usually difficult, and the use ofsome clinical clues, high-resolution computerized tomography, and histopathologic findings in lung biopsy could help to differentiate between the various entities. These diseases are caused by proliferative abnormalities of cells of the mononuclear phagocyte system and their principal cell, the histiocyte. zurück zum Suchergebnis. Although the presenting, symptoms and physical examination are commonly, nonspecific, the lack of a current or prior cigarette-, smoking history renders the diagnosis of PLCH, findings, certain clues may suggest PLCH. Second case is 34 years old man with 15 pack/years smoking history was admitted with persistant cough. Kunnen longen zich herstellen na jarenlang roken? PET/CT was done, with CT demonstrating classic pulmonary manifestations of Langerhans cell histiocytosis that had association with intense FDG uptake on PET.

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